Samantha Akkineni was born to Prabhu and Ninette family. She made her film debut with the telugu Tollywood Film Ye Maaya Chesave released on 26 February 2010 as Jessie Thekkekuttu , which was also being shot in tamil simultaneously as Vinnaithaandi Varuvaayaa. Ye Maaya Chesave directed by Gautham Menon produced by Manjula Ghattamaneni and Sanjay Swaroop.
Samantha Akkineni married to her love interest Naga Chaitanya whos is actor by profession in Telugu Film Industry. Naga Chaitanya and Samantha Ruth Prabhu married on 6th October 2017 in Goa accordingly Hindu traditional rituals and on 7 October 2017 as per Christian customs.